As the daughter of a talented musician, Xiao Zhou Zhou definitely inherited her father’s talent in music, the song “former lover”, is Jay Chou according to his daughter’s four-month-old “playing” the melody and created. People have to marvel at the power of genes. However, as wonderful as it is to inherit a father’s talent, fans are beginning to worry about whether little Hathaway will also inherit her father’s disease. As we all know, Jay has “hereditary ankylosing spondylitis”. This is a chronic inflammatory disease caused by autoimmune problems that mainly affects the joints of the spine and nearby soft tissues such as tendons and ligaments. Rigid spondylitis has a destructive effect on the body’s skeletal tissues. At the onset of the disease, the back pain can be so severe that it is impossible to lie down and sleep normally, and you may even need to take painkillers to relieve it. Once spondylitis occurs, it progresses irreversibly, with the following characteristics: inflammation of the spine, hip bones, and pelvis → calcification and stiffness of the bones and joints → inability to bend the spine and loss of elasticity → spreading of the inflammation and stiffness up and down the spine. After the inflammation subsides, bone spurs will appear on the top and bottom of the spine, making it hard to bend and painful. Therefore, in addition to spinal stiffness, patients are also prone to pain due to inflammation of the ligaments and tendons of the bones. The cause of spondylolisthesis is not clear, but may be related to genetics (HLAIB27, a white blood cell antibody in the human body), immunity and infection. Currently, the only treatments for this condition are medication to control inflammation and physical therapy to maintain joint mobility. In severe cases, the hunchback deformity can be corrected surgically, and in cases where the condition is so severe that the patient is unable to walk, an artificial hip joint is surgically inserted depending on the patient’s condition. However, although ankylosing spondylitis is hereditary, the disease is not highly hereditary, and only a few individuals in a family (average prevalence of about 4%) develop the disease, while the majority of people remain free of the disease for life. On the other hand, the disease has a high sex ratio of about 10:1, which means that the possibility of a baby girl inheriting her father’s disease is even smaller. In addition, the disease also has the following two characteristics: 1, in the “rigid spondylitis” family population, the general condition of the father’s generation is heavier than the children’s generation, the condition of the male patient is heavier than the female patient, and the age of onset of the disease and the severity of the disease has no obvious relationship; 2, in the family of many children, the prevalence of late-born children is higher than that of the early-born children, and the rate of the last-born children is higher than that of the first-born children. In a large family, the prevalence of late-born children is higher than early-born children, and the prevalence of last-born children is higher than first-born children. Finally, if you have hereditary ankylosing spondylitis and are worried about whether your baby will be affected by the disease, you can take your child for a blood test to check for HLA-B27, which is usually available in large hospitals with rheumatology departments. Now it seems that you can rest assured that little Chou-Chou will grow up healthy and happy with his dad’s musical talent!