Staphylococcus aureus is currently preferred to penicillinase-resistant semisynthetic penicillins such as benzathine sodium or aminoglycosides such as cephalosporins and amikacin. At present, S. aureus has a very high rate of resistance to penicillin, so at present, benzoxacillin sodium, cloxacillin and other penicillinase-resistant semi-synthetic penicillin or cephalosporins are often chosen; aminoglycosides such as amikacin can also be applied in combination. Part of the population application of amoxicillin, ampicillin, etc. is also effective. Some people are resistant to methicillin drugs, this kind of people usually need to carry out the drug sensitivity test of vancomycin and other drugs, if sensitive, yea can apply vancomycin, ticoranin and other antibiotics for treatment. When infected with Staphylococcus aureus, empirical medication should be administered under the guidance of a doctor, along with drug sensitivity tests, to select sensitive drugs for treatment.