The pain in the middle of the eyes may be caused by visual fatigue, elevated intraocular pressure or sinusitis. 1. Visual fatigue: If the patient has a long time of close vision, the focus of vision has been concentrated on the closer objects, resulting in ciliary muscle spasm, which can cause visual fatigue, resulting in patients with pain in the middle of the eyes. 2. Elevated intraocular pressure: glaucoma patients with elevated intraocular pressure, the wall of the eyeball is under pressure, which can stimulate the pain nerve fibers on the wall of the eyeball, resulting in patients with pain in the middle of the eye discomfort symptoms. 3. Sinus inflammation: Sinuses are divided into four groups, including frontal sinus, maxillary sinus, sieve sinus, pterygoid sinus, if the patient suffers from sinus inflammation, especially frontal sinus area of the inflammation, easy to appear involved in the pain, the patient can be manifested as pain in the middle of the eyes. It is recommended that patients with significant pain in the middle of the eyes consult a regular hospital in a timely manner to assess their condition and follow the doctor’s instructions for treatment.