Prediabetes can be reversed clinically by improving the patient’s islet function in many ways. There is no uniform standard for reversal, but one can generally focus on diabetes reversal in terms of both glycemic control and monitoring the patient’s islet function. Intensive treatment of prediabetes can bring blood glucose to a standard of good control, indicating some recovery of islet function. The monitoring of patient’s islet function mainly observes two indicators: the amount of insulin secretion and the temporal phase of insulin secretion. If the patient’s own insulin secretion can be restored after intensive treatment of pre-diabetes through insulin, the patient’s insulin secretion can be restored. The peak forward shift of insulin secretion curve is considered to be a recovery of islet function, and this is also considered to have some reversal. In order to achieve such a goal, intensive treatment is required at a relatively early stage, i.e., when diabetes is first detected, with integrated management of blood glucose, lipids and blood pressure. Through intensive treatment with integrated management, the patient’s islet function is restored, and the amount and timing of insulin secretion is restored.