It is recommended to take cold medicine at least 24 hours after drinking white wine because alcohol and cold medicine are prone to allergic reactions, also known as disulfiram-like reactions. When such a reaction occurs, it may lead to anaphylaxis and even endanger the patient’s life. At the same time itself, oral cold medicine can increase the burden of liver and kidney and other organs, and alcohol is also metabolized through liver and kidney, which can increase the chance of liver damage and kidney insufficiency. Therefore, it is recommended that drinking alcohol must be strictly forbidden during the cold, and cold medicine should not be taken immediately after drinking alcohol, especially when the cold is combined with bacterial infection, which requires antibiotics, and antibiotics are prone to further allergic reactions with alcohol, thus causing greater physical harm to people.