It is not appropriate to say the signs of late-stage bile duct cancer. Late-stage bile duct cancer is mainly judged from clinical symptoms, and patients will have obvious pain, jaundice, multi-organ failure and so on. 1. Obvious pain: most patients with advanced stage of cholangiocarcinoma have obvious pain, which is mainly due to the enlargement of tumor infringing on nerves, resulting in nerve compression and pain. 2. Jaundice: the main reason of jaundice is that bile duct obstruction caused by growing cholangiocarcinoma results in cholestasis, which is manifested as yellowing of skin and mucous membrane, whitish color of stools, etc. With the progress of the disease, jaundice encephalopathy may even be induced. 3. Multi-organ failure: patients with advanced stage of cholangiocarcinoma can suffer from multi-organ failure, which may manifest as respiratory failure, heart failure and so on. In addition, tumor can release inflammatory factors (such as tumor necrosis factor, etc.), which can lead to symptoms such as elevated body temperature; if metastasis occurs, metastasis-related symptoms can appear, such as chest pain, hemoptysis, etc. in lung metastasis. In conclusion, cholangiocarcinoma will cause symptoms such as jaundice, abdominal discomfort and pain. If you have the above discomfort, it is recommended to go to regular hospitals for consultation and treatment, follow the doctor’s instructions to actively cooperate with the treatment, and choose the appropriate treatment plan to avoid delaying the condition.