The 5-year survival rate of conventional stage II gastric cancer is about 55%; while the 5-year survival rate of stage III gastric cancer is between 15% and 30%. Radical resection of intermediate gastric cancer is performed surgically, and additional regular chemotherapy is required after surgery. The sensitivity of each patient to chemotherapy is different, that is, each person has different response to chemotherapy drugs, and the tumor has different effect on chemotherapy drugs, which also directly affects the survival time of patients after surgery. The more sensitive to chemotherapy, the more chances of tumor killing and the higher survival rate in 5 years. And it has a certain relationship with the size of tumor volume, whether it invades the plasma membrane during surgery and whether it has lymph node metastasis and vascular invasion. Overall, the treatment effect of stage II and III intermediate gastric cancer is worse than early stage, but better than stage IV advanced gastric cancer.