Patients with anal fissures can be treated with topical application of Ma Ying Long hemorrhoid cream. However, whether satisfactory results can be achieved by using Ma Yinglong hemorrhoid cream alone depends on the severity of the anal fissure. For mild anal fissures, it is possible to apply Ma Yinglong hemorrhoid cream alone; for severe anal fissures with pain and bleeding, applying Ma Yinglong hemorrhoid cream alone may achieve a very limited therapeutic effect. The clinical treatment for anal fissures often uses drugs such as nitroglycerin or diltiazem, erythromycin ointment topical treatment, together with the use of anal pessary or Ma Yinglong hemorrhoid suppositories, Puji hemorrhoid suppositories nano-anal for comprehensive treatment, which can play a very good therapeutic effect. Of course, it is also very important to keep the bowels open, eat more dietary fiber foods and fruits containing more seeds, laxative, can promote wound healing.