In recent years, the incidence of Premature Ovarian Failure (POF) has increased dramatically, resulting in a higher rate of loss of fertility. Many patients with POF are overly obsessed with the need for hormone replacement therapy, and therefore consult multiple doctors, each of whom may have a different viewpoint, causing great confusion for the patient. Through a lot of clinical experience, it is concluded that it is necessary to give standardized and natural hormone replacement therapy to young POF patients. While improving the quality of life, they can also receive embryo transfer in due course. This is because, firstly, through hormone replacement therapy, the uterus can be maintained from excessive atrophy, and if there is a condition of egg supply, embryo transfer with egg supply can be accepted at any time. Secondly, it can reduce the speed of breast atrophy, so that the patient’s self-confidence in life can be increased and the quality of life can be improved. Third, slow down the speed of osteoporosis, and need to get more sunshine, strengthen exercise. Fourth, slow down the speed of skin aging. Before receiving hormone replacement, it is necessary to standardize the examination of the breast, ovary, uterus, etc. for the presence of estrogen-dependent tumors.