Aminotransferases are essential catalysts of human metabolism. The commonly used aminotransferases in clinical practice are alanine aminotransferase (ALT, also known as glutamate aminotransferase) and aspartate aminotransferase (AST, also known as glutamate aminotransferase). The normal reference value of both aminotransferases is 10-40U/L. When it is higher than this value, it is called high aminotransferase, which can be seen in the following cases: 1. If the person being examined has strenuous exercise before the blood draw, such as fatigue, alcohol consumption, staying up late, fever, etc., it can interfere with the metabolism of the body and cause a mild transient increase in aminotransferase. 2, drug factors: taking compound aspirin, ibuprofen and other non-steroidal anti-inflammatory drugs and certain antibiotics, anti-epileptic drugs and anti-tuberculosis drugs have the side effect of damaging liver cells and causing elevated transaminases, which can be gradually restored after stopping the drugs. 3, liver disease: fatty liver, various types of viral hepatitis, alcoholic liver disease, immune liver disease and other liver diseases can cause liver cell damage, causing different degrees of aminotransferase elevation. 4, other: transaminases can exist in various tissues in the body, so myocardial infarction, myogenic diseases, hyperthyroidism, hepatomegaly and other diseases can also damage the body’s tissues and cause transaminases to rise. In summary, elevated transaminases can be seen in non-pathological causes such as strenuous exercise and exertion, but also in pathological factors such as liver disease and myocardial infarction, etc. A clear diagnosis needs to be made by combining the patient’s medical history and other laboratory and examination indicators.