Low mood always appear, may be depression, depression patients in most of the time every day to appear low mood, slow thinking, will activities to reduce, and often poor diet, sleep, self-interests are affected, lack of interest in fun and lack of pleasure, self-evaluation is relatively low as well as the emergence of self-guilt and self-loathing, this long-term low mood as the main prominent symptom, accompanied by in every day! This long-term depression as the main prominent symptoms, accompanied by every day of life, and the patient can not be happy, depressed mood depression, nothing of interest, can not lift the spirit, so for the patient has no pleasure to speak of. For this situation, systematic and standardized treatment should be carried out, including the application of new antidepressant 5-hydroxytryptamine reuptake inhibitors, such as venlafaxine, duloxetine, paroxetine, fluoxetine and other related drugs, in the case of adequate amount of full course of systematic and standardized treatment, the symptoms of depressed mood can be completely cured.