Severe acute angle-closure glaucoma can cause lens changes, and translucent porcelain white or milky white cloudy spots can be seen under the anterior capsule of the lens in the pupil area, called glaucoma spots. Overexertion, lack of sleep, mood swings, poor diet or overeating can affect the vascular nerve regulating center and make the vasodilation and contraction dysfunction: on the one hand, it can make capillaries dilate and vascular permeability increase, causing ciliary muscle edema and anterior shift, blocking the anterior chamber angle and making the atrial water outflow channel obstructed, on the other hand, it can make the atrial water secretion too much, the posterior chamber pressure is too high, and the peripheral iris is pressured to move forward and make the anterior chamber shallow. The anterior chamber becomes shallow and the anterior chamber angle becomes narrower. All of these factors can cause a dramatic increase in IOP, leading to an acute attack of glaucoma. Severe acute closed-angle glaucoma can cause lens changes. Hypertension Hypertension is a special phenomenon that has been gradually recognized after decades of clinical experience in the diagnosis and treatment of primary open-angle glaucoma. In clinical work, it has been confirmed that the majority of patients with clearly diagnosed glaucoma have the common feature of elevated IOP. Although hypertension develops slowly and causes less optic disc and visual field damage, it has an important pathological factor in common with open-angle glaucoma, namely elevated intraocular pressure. Primary acute angle-closure glaucoma Primary acute angle-closure glaucoma (APACG) is a type of glaucoma in which the atrial angle closes, causing an acute increase in intraocular pressure. Pupillary block is the main mechanism of this type of glaucoma, which means that the vast majority of patients with acute angle-closure glaucoma are pupillary blocked, but a few patients are non-pupillary blocked. Complicated cataract Complicated cataract refers to a localized lesion of the eye that causes abnormalities in the local epithelium or internal metabolism of the lens or erosion of the lens by the inflammatory and degenerative products of the local lesion, resulting in lens clouding. In essence, cataracts that are caused by systemic or localized lesions of the eye fall under the category of complicated cataract. The morphologic features of lens clouding are related to the primary disease. True microphthalmos True microphthalmos (nanophthalmos) is a condition in which the eye stops developing after the embryonic cleft closes during fetal development, and the eye is smaller than normal without other congenital malformations. The typical microphthalmos has clinical features such as small eyeball, small cornea, shallow anterior chamber, narrow atrial angle, thick sclera, normal size lens or spherical lens, and macular dysplasia. Therefore, it has the tendency to develop closed-angle glaucoma and spontaneous uveal leakage with increasing age, and is poorly treated, so it is a potentially devastating eye disease that can cause blindness with improper management.