Although in principle there is no direct correlation between Hepatitis B vaccine and HPV vaccine, it is not recommended to take Hepatitis B vaccine and HPV vaccine at the same time. Hepatitis B vaccine is a genetically engineered vaccine, which has no toxicity to the human body, and is one of the most effective measures for preventing hepatitis B virus infection, and the injection method is to be completed within six months according to the order of 0, 1, 6. HPV vaccine is also known as human papillomavirus vaccine, which is mainly used to prevent cervical cancer. There are mainly 2-valent, 4-valent and 9-valent on the market now. Hepatitis B vaccine and HPV vaccine are both inactivated vaccines, and the principle of both vaccines is to stimulate the body to produce protective antibodies to effectively prevent the virus. If both vaccines are required, it is recommended that they be administered separately, as simultaneous vaccination may have an effect on the body and lead to adverse reactions. Vaccination can be given at intervals according to the timing of the two vaccines, and different parts of the body need to be selected for vaccination.