Diagnosis 1. Abdominal pain, mostly manifested as right upper abdomen or (and) middle and upper abdomen distension or colic, pain may radiate to the right shoulder and back. It may be accompanied by nausea and vomiting, often after exertion or eating fatty food. The attack may be accompanied by fever, and the interictal period is mostly asymptomatic or only shows indigestion symptoms such as postprandial epigastric fullness, eructation, belching, etc. 2. In acute attacks, there are more signs of epigastric pain or limited peritonitis, positive Murphg’s sign, jaundice in about 20%-25% of patients, and generally no positive signs in the interictal period. 3. Ultrasound shows enlarged or atrophied gallbladder, thickened and gross gallbladder wall, and gallbladder stones. 4. There is an increase in white blood cell count and neutrophils during acute attacks, and a mild increase in bilirubin or transaminases. Treatment principles Except for asymptomatic solitary gallbladder stones, which can be left untreated, all other cases should be treated actively and early. (1) Non-surgical treatment: (1) Indications: first attack, mild inflammation, less severe symptoms, patient unwilling to operate; asymptomatic gallbladder stones; as a preparation before surgery. (2) Methods: anti-infection, antispasmodic, biliary; diet control, fasting if necessary, gastrointestinal decompression; correction of water, electrolytes and acid-base balance imbalance, supplementation of energy and multivitamins. Surgical treatment: (1) Indications for surgery: acute cholecystitis in which conservative treatment is ineffective; chronic cholecystitis and gallstones with recurrent right upper abdominal pain and/or persistent dyspeptic symptoms; asymptomatic gallbladder stones for which the patient requires surgical treatment; inflammation and/or obstruction of the intra- and extrahepatic bile duct system; acute purulent, gangrenous or obstructive cholecystitis complicated by biliary peritonitis or perforated should be Emergency surgery. (2) Pre-operative preparation Complete relevant tests, including three major routine tests, liver and kidney function, coagulation function, hepatitis series, syphilis antibody assay, anti-HIV assay, ECG, chest X-ray, abdominal ultrasound, etc. For patients with other chronic diseases, such as hypertension and diabetes mellitus, relevant tests should be monitored to control the existing diseases and improve the tolerance of surgery. (3) Surgical methods Conventional open cholecystectomy. Laparoscopic cholecystectomy: If there is no history of upper abdominal surgery, patients who are suitable for simple cholecystectomy can have their gallbladders removed laparoscopically. It has now become the preferred surgical procedure for removal of the gallbladder. Cholecystostomy. A, extensive adhesions around the gallbladder, heavy inflammation and unclear anatomical relationships; B, old and frail or critically ill patients who cannot tolerate cholecystectomy; C, gallbladder perforation surrounded by large omentum to form an abscess. Cholecystectomy plus common bile duct exploration. Applicable to patients with biliary obstruction conditions. Efficacy criteria 1.Cure: disappearance of symptoms and signs after surgery, no complications and healing of incision. 2.Improved: Symptoms and symptoms basically disappeared after drug treatment. 3.Not cured: untreated patients.