Daytime fatigue and nighttime spirits have the following possible causes: First, patients often work at night and sleep during the day, and after a long time, they will have daytime fatigue and nighttime spirits. Second, daytime fatigue and night spirit may also be caused by anxiety and depression, it is recommended that patients go to a mental health center and give psychological treatment, and serious patients can be given anti-anxiety and anti-depression treatment. Third, daytime fatigue and nighttime energy may also be the manifestation of neurasthenia and serious subhealth state. Patients are advised to go to the neurology department and improve the corresponding examination to clarify whether there is organic disease. For patients with neurasthenia, glutathione and B vitamins can be given as treatment. For patients with severe sub-health, acupuncture and physical therapy can be given to improve the symptoms.