If a patient has a transfusion reaction, the first thing to do is to determine the severity of the reaction. If it is a mild transfusion reaction with only limited and peripheral itching and urticaria, it is not necessary to stop the transfusion, and it can be gradually improved by oral anti-allergic drugs and intravenous glucocorticoids. Severe allergic reactions must immediately stop blood transfusion, and the patient for the whole process of monitoring, monitoring the patient’s vital signs, such as heart rate, blood pressure, pulse, arterial oxygen saturation, body temperature, urine output, etc.. If the patient develops angioneurotic edema, hydrocortisone should be applied, and tracheal intubation or tracheotomy should be performed if necessary to keep the airway open. For severe allergic reactions, it is recommended to enter a small amount of plasma, platelets or washed red blood cells and other components of blood transfusion to reduce the allergic reaction.