It is common in squamous carcinoma, adenocarcinoma and small cell lung cancer and can occur in both men and women. Patients improve in 94.4% after chemotherapy or surgery and often have hypertrophic pulmonary osteoarthropathy, which refers to symmetrical joint pain, with the most common involvement of the ankle, knee, wrist and elbow joints. Pestle finger X-ray shows new bone periosteum formation, and high uptake of periosteal surface on nuclear imaging and presumably related to humoral antigens, and also reported presumably due to secretion of growth hormone, long-acting thyroid stimulants, and vasodilator substances by tumors in lung cancer patients.