The first thing you should focus on is self-care for pus in the toe nail infection, to eliminate inflammation and prevent infection. You can use iodophor for disinfection to prevent further infection, and you should pay attention to daily cleaning and care. If the onset of nail infection is serious, other related treatments are needed: 1. Medication: When the degree of suppuration is light, the scope is not very large, and the pus in the nail area is less, you can use Dragon Pearl ointment topical application, which can promote the discharge of pus, so that the local inflammation subsides. You can also use ichthyolite ointment topically, which can promote pus drainage and inflammation subsidence. It is also necessary to take oral antibiotics as prescribed by the doctor, such as roxithromycin, cephalosporin antibiotics, etc.; 2. Surgical treatment: If the degree of suppuration is serious and there is an obvious sense of fluctuation, surgical incision and drainage is needed in time to drain the pus completely. If the scope of inflammatory reaction is large, partial removal of the toenail should be performed. In more severe cases, toenail removal surgery is required, followed by braking and compression bandaging. Toenail fungus, being at the end of the body, has poor circulation, so absorption and healing are relatively difficult, and it is more likely to become septic. If it develops into a more severe septic lesion, treatment becomes more complicated and may also affect the prognosis.