When patients wake up with swollen eyes, it may be due to lack of sleep, and may also be caused by blepharitis, conjunctivitis and other diseases. 1. Lack of sleep: prolonged insufficient sleep or frequent use of the eyes can lead to visual fatigue, and patients may experience eye swelling and pain, which can also be accompanied by drowsiness, fatigue and other uncomfortable symptoms. 2. Blepharitis: Blepharitis is an inflammatory infection of the eyelid glands, usually associated with staphylococcal infection. The main symptoms are redness, swelling, warmth and pain in the eyes, which can be aggravated by rubbing the eyes before going to bed or not paying attention to eye hygiene. 3. Conjunctivitis: viral and bacterial infections can cause inflammation of the conjunctival tissue, and under the stimulation of inflammation, patients can experience redness, itching and other symptoms, and patients can also be accompanied by an increase in eye secretions. It is recommended that patients with obvious eye swelling and pain should consult a doctor to assess their condition and follow the doctor’s instructions for treatment.