The probability of contracting tuberculosis with biologics is possible, but it is not possible to generalize, because there are significant differences in the physical condition of each person, for example, people with autoimmune diseases have a higher risk of contracting tuberculosis with the use of biologics than the general population. Biologics are substances made from carbon-based organisms that have medical research value, and are referred to in medicine as immunobiologics, which have preventive, therapeutic, and diagnostic effects. The use of biologics may lead to tuberculosis infection, either by stimulating latent tuberculosis infection or by weakening the body’s immune system, leading to secondary tuberculosis infection. However, there are no accurate data on the probability of contracting TB infection from inoculation with biological agents. Whether or not the use of biological agents can trigger TB infection is related to a number of factors. Individuals should be screened for tuberculosis before using biologics, and after use, they should closely observe changes in their bodies and be tested in a timely manner, and intervene in a timely manner when tuberculosis infection is suspected, in accordance with their doctor’s instructions.