Buttock groove sweat grinding pain should pay attention to the cleanliness of the affected area, keep the local dry, topical astringent protective drugs such as zinc oxide ointment, glucocorticoid drugs treatment. Buttock groove sweating grinding pain refers to the affected area due to sweating, resulting in the stratum corneum of the skin impregnated and swollen, folded parts of the erythema, the formation of vesicles, resulting in pain and even itching, severe vesicles secondary infection. The treatment should be away from the high temperature environment, underwear should be loose and breathable, pay attention to the cleanliness of the affected area, keep dry, external astringent protective agent, anti-inflammatory ointment and other drugs treatment. 1. Astringent protective drugs: commonly used such as zinc oxide ointment, rubbed externally on the affected area, has the effect of astringent, dry and protect the skin. Note: If there is redness, swelling and burning sensation at the site of the drug, the drug should be stopped and the drug should be washed off. 2. Anti-inflammatory drugs: when the affected area is infected, topical fusidic acid cream can be used as antibacterial and anti-inflammatory to relieve and eliminate symptoms. Its adverse reaction is the use of drugs may appear after a slight burning sensation of the skin, pins and needles feeling, to wash clean and stop using the drug in time. Buttock groove sweat grinding pain should be timely consultation, under the guidance of the physician’s medication, do not self-medication, to avoid causing adverse consequences.