Tacrolimus is very clear and effective in the treatment of nephrotic syndrome. The main mechanism of action of this drug is to inhibit the proliferation of B-lymphocytes, thus inhibiting the production of interleukin-2, which in turn inhibits the action of downstream factors, thus acting as a treatment for nephrotic syndrome. According to the published literature and data, the effect of combining 1/4 dose or half dose of glucocorticoids in the treatment of nephrotic syndrome is completely superior to the effect of the most classical full dose of glucocorticoids combined with cyclophosphamide. However, abnormalities in metabolic indicators such as blood glucose, lipids and blood pressure may occur during the use of this drug, and these side effects will gradually disappear with the gradual reduction or discontinuation of the drug.