Clinical determination of whether a virus has invaded the body can be performed by applying three main methods: nucleic acid testing, antigen testing and antibody testing, of which both nucleic acid testing and antigen testing can directly detect the virus. Antigen testing is done mainly by detecting the antigens of the virus, while nucleic acid testing mainly detects the genes of the virus, while antigens are the outer shell of the virus and can be detected more easily. Compared to nucleic acid testing, antigen testing is faster and easier to perform, but at the same time the accuracy will be lower. Therefore, antigen detection can be used for early screening of novel coronavirus infections, which can help to detect infected individuals early and better facilitate outbreak prevention and control. After the discovery of the Omicron variant, the virus spread faster and the number of virus carriers increased in a short period of time, making it more difficult to prevent and control the epidemic. Antigen testing, as a complementary means of screening, can screen suspected infected people faster, and residents can perform the test themselves at home, which can help relieve the pressure of nucleic acid testing in hospitals. Positive antigen results can be used for early triage and rapid management of the suspected population, but it should be noted that antigen testing is not a substitute for nucleic acid testing, which is still the basis for confirming a diagnosis of a new coronavirus infection. For those with positive antigen test results, regardless of whether they have cough or fever, they should immediately report to their community or village, do the relevant isolation measures and then go to the local designated fever clinic for nucleic acid testing, and the results of the nucleic acid test shall prevail whether they are infected or not.