Hepatitis B E antibody negative indicates that it is within the normal range, if it is hepatitis B e antigen positive, hepatitis B e antibody negative, it means that the disease is in the active stage, the amount of viral replication is relatively more, it is in the period of viral replication, it is more infectious, and it needs to be treated with antiviral therapy in time. If you are positive for hepatitis B e antigen and negative for hepatitis B e antibody, you should use entecavir dispersible tablets, tenofovir disoproxil fumarate tablets, tibivudine tablets and other medications in moderation under the guidance of a doctor to avoid overdose causing adverse reactions. Hepatitis B is generally caused by HBV circulating immune complex deposition, HBV direct infection of the cells of the kidney, HBV infection leads to human immune dysfunction and other factors, may appear proteinuria, hematuria, elevated blood pressure and other symptoms. If you suffer from hepatitis B in daily life, you should pay attention to ensure sufficient sleep to avoid overwork, pay attention to keep warm to avoid catching cold, keep the skin area dry and clean. If there is any discomfort, you should consult a doctor in time.