Patient, female, 60 years old. Nearly 2 years ago, she underwent nasal polypectomy at the local local hospital. Postoperative pathology reported chondrosarcoma. So she went to the provincial university hospital for another surgery. One year later, recurrence occurred again. He went to the attending doctor again. The tumor was found to be located in the pterygoid sinus, invading the slope, pterygoid process (right side), pterygoid fossa, infratemporal fossa, and near the base of the right middle cranial fossa. The local physician recommended a referral as shown below. The patient sought consultation to our office. After complete examination, we used transnasal endoscopy to completely resect the tumor in the pterygoid sinus, the slope, the bilateral pterygoid process, and the base of the middle cranial fossa. The patient recovered quickly after surgery and was discharged a week later. The patient was advised to undergo postoperative radiotherapy. However, the patient insisted to go home for treatment. Follow-up is currently in progress. Chondrosarcoma is a malignant tumor of bony, cartilaginous origin that occurs mostly in the midline region at the base of the skull in the sinus region. Surgery is the only effective treatment. However, given the close relationship between the skull base area of the sinuses and the skull base, brain, orbit, optic nerve and arteries, among other important structures, surgery is the only effective treatment. Therefore, an experienced surgeon is needed to try to achieve complete surgical excision. Postoperative follow-up is intensive. Radiotherapy and chemotherapy with uncertain results ….. It is currently proposed that proton heavy ion radiotherapy may be more effective than conventional radiotherapy. However, international and domestic follow-up experience is still accumulating. Treatment should be individualized and tailored to the individual.