After 4 failed IVF attempts, it is generally necessary to look for the cause before proceeding with the treatment, and the follow-up should also improve the relevant examinations, and if the failure is caused by diseases, medication or surgical treatment can be carried out. 1. Improvement of relevant examinations: If there are uterus-related diseases or autoimmune abnormalities and other diseases, it is recommended to consult a doctor in time for hysteroscopy and other relevant examinations to clarify the cause of the disease and then carry out follow-up treatment. 2. Medication: repeated failure of IVF may be related to cervicitis, autoimmune abnormalities, antiphospholipid syndrome and other diseases. It is recommended that reproductive endocrinologists combine with rheumatologists and immunologists for comprehensive treatment. 3. Surgical treatment: If there are diseases such as uterine fibroids, uterine polyps, cervical cancer, etc., which may also lead to repeated failure of IVF, surgical treatment can be carried out to remove polyps or fibroids. As we can see, when IVF fails repeatedly, it is recommended to choose regular hospitals for embryo transfer, avoid excessive tension and anxiety after the transfer, strictly follow the doctor’s instructions on medication and pay attention to care, and choose to transfer again according to the situation after the body recovers.