Positive direct anti-human globulin test is due to the presence of incomplete antibodies on the surface of red blood cells of the tested person, and it is considered that the patient may have autoimmune anemia, transfusion reaction caused by incompatible red blood cells, and so on.
Anti-human globulin test is known as Coomb’s test, which is divided into direct anti-human globulin test and indirect anti-human globulin test. Direct anti-human globulin test should be negative under normal circumstances, while a positive result suggests that the patient may have autoimmune anemia, transfusion reaction caused by red blood cell dyscrasia and other conditions.
In addition, systemic lupus erythematosus, malignant lymphoma, infectious mononucleosis, lead poisoning and other conditions may also lead to a positive direct anti-human globulin test. Patients with abnormal results of this test should complete the relevant auxiliary examinations such as routine blood tests and red blood cell fragility tests in order to further clarify the cause.
It is recommended that patients with positive direct anti-human globulin test should go to hematology, rheumatology and immunology departments of regular hospitals for detailed consultation.