Insulin, as a key class of drugs in glycemic control of diabetes, has been widely accepted by physicians and patients and is being used in an increasing number of patients. The numerous issues of how to improve the effect of insulin, improve the therapeutic effect, minimize the dose of insulin use, reduce the cost of treatment, and mitigate potential adverse effects have become a concern for many physicians and patients. Control of overweight and obesity is an important cause of insulin resistance and reduced sensitivity of the body to insulin, and one of the important reasons for the abnormally large amount of insulin dosage in many patients with clinical application of insulin. In addition, due to the promoting effect of insulin on the body’s anabolism, as well as the increase in adipose tissue and water and sodium retention, the weight of patients using insulin will continue to increase, which is also one of the reasons for the increasing insulin dosage. With the reduction of body weight and improvement of insulin resistance, insulin dosage can be reduced and the normal function of insulin secretion by pancreatic islet cells can be effectively protected, which is conducive to the protection of endogenous insulin secretion capacity. With the restoration of the body’s endogenous insulin secretion capacity, the amount of exogenous insulin can also be reduced to a certain extent. Good exercise habits Suitable exercise helps insulin to function, accelerates the use of glucose by the body’s relevant tissues such as muscle and fat, and to a certain extent can increase insulin sensitivity. It should be noted that diabetic patients should combine their own characteristics and choose an exercise mode suitable for their conditions to avoid hypoglycemia during exercise and excessive body consumption caused by excessive exercise. The dose of insulin should be adjusted slightly according to the changes of diet and exercise habits of each person. The reasonable use of insulin at each meal has an irreplaceable role in the effective and safe control of blood sugar. If the body has some acute diseases or emotional excitement and other stressful situations, the body’s sympathetic excitement and glucagon secretion will increase, which will weaken the effect of insulin, so the active control of various stressful situations also has a significant role in the full effect of insulin. Use of appropriate insulin form Generally speaking, the dose of animal insulin will be greater than that of human insulin, and the dose of human insulin will be greater than that of human insulin analogues. Therefore, according to the different conditions of each person, the appropriate type of insulin should be chosen to obtain ideal blood glucose control. The use of insulin sensitizers such as insulin sensitizers rosiglitazone, pioglitazone and metformin can increase the sensitivity of muscle, fat, liver and other tissues to insulin, improve insulin resistance and promote insulin action, thus reducing insulin dosage. Active treatment of metabolic abnormalities Diabetic patients have a variety of metabolic abnormalities at the same time, such as hyperlipidemia, blood hyperviscosity state, hyperuricemia, etc., and these metabolic abnormalities can also damage islet cells and promote insulin action insensitivity, so active treatment of these metabolic abnormalities at the same time and comprehensive control of metabolic state can improve the body state to a large extent and help improve insulin action.