Children’s antipyretic suppositories and oral medications have the same effect, and some children have difficulty cooperating with oral intake, so compliance with suppositories is better. Commonly used antipyretic suppositories for children are pediatric ibuprofen suppositories, acetaminophen suppositories, and commonly used antipyretic medications are ibuprofen suspension and acetaminophen dry suspension, which are similar in main ingredients and are mainly used for children’s fever caused by the common cold or influenza, but also used to alleviate mild to moderate pain such as headache, arthralgia, migraine, toothache, muscular aches and pains, and neuralgia. Therefore, antipyretic suppositories and oral medications have similar effects, and for some children who are difficult to cooperate with oral medications, antipyretic suppositories can be used. In addition, it should be noted that the use of medication to reduce fever should be at least 4 hours apart, and the number of times used in 24 hours should not be more than 4 times. Avoid using other antipyretic and analgesic drugs during the use of the drug. This is because these medications often contain the same antipyretic ingredients, which can inadvertently lead to overdose of fever-reducing medications in children. All of the above medications should be used under a doctor’s supervision, avoiding self-medication. There are many causes of fever in children, it is recommended to go to the hospital in time, do not blindly use medication, so as not to delay the condition.