1, chronic kidney disease clinical manifestations are complex and diverse From the clinical point of view: most patients mainly proteinuria, some proteinuria less, some proteinuria large amount; some mainly hematuria, recurrent; some proteinuria with hematuria; some no clinical symptoms, usually no history of chronic kidney disease, to the hospital examination but found a serious decline in kidney function, some patients a serious cold, lung infection clinical hospitalization treatment But the kidney function is found to decline sharply. 2, chronic kidney disease is divided into primary and secondary primary kidney disease mainly refers to primary nephrotic syndrome, acute nephritis, or past occult nephritis, secondary kidney disease in children is the most common allergic purpura kidney, the most common female is systemic lupus erythematosus involving kidney damage (lupus kidney), some patients are hepatitis B-related nephritis, amyloidosis in the elderly, middle-aged and elderly patients can also see myeloma kidney damage, and some patients with aristolochic acid nephropathy caused by taking proprietary Chinese medicines, etc. With the improved understanding of renal pathology, it is more difficult to obtain clinical analysis of chronic kidney disease by clinical cognition alone, and many renal pathologies have far surpassed the past understanding, such as purpura kidney and IgA nephropathy, clinical nephropathology almost shows a very high consistency, only purpura kidney extra-renal clinical manifestations are accompanied by abdominal pain, rash, arthralgia, purpura kidney is mostly seen in children, IgA nephropathy is seen in young and middle-aged patients. The diabetic nephropathy has been considered to be the most common cause of diabetes. Diabetic nephropathy in the past has been considered a chronic progressive process, modern look at diabetic kidney damage includes a variety of clinical manifestations of chronic kidney disease, especially the clinical sudden appearance of a large amount of proteinuria, hypertension, renal function declined sharply patients, we should pay attention to the diabetic kidney pathology damage for chronic kidney disease damage accompanied by acute kidney injury changes, and acute kidney injury pathology can appear crescent formation, small vessel inflammatory The progression of renal pathology can be exacerbated by crescent formation, small vessel inflammatory damage, and massive inflammatory cell infiltration in the renal interstitium.