Q: What about infertility in women with pituitary adenoma? A: Infertility in women with pituitary adenoma is closely related to hyperprolactinemia. Only by effectively reducing the increased prolactin can infertile women regain their fertility. Opinions differ as to what treatment should be used first for those with pituitary tumor infertility. Studies have found that bromocriptine alone for tiny pituitary adenomas resulted in a significant decrease in blood PRL that was maintained at a low level within 4 weeks. Ovulation resumed, menstruation resumed, and lactation stopped in about 70-90% of patients within 6-8 weeks of treatment. As the serum PRL level decreases, the blood LH and FSH levels increase to normal and the infertile patient regains fertility. The fertility rate after treatment of pituitary microadenomas with transsphenoidal surgery is 91%, and the fertility rate for large adenomas is 75-88%. Fertility rates for diffusely growing large pituitary tumors treated with bromocriptine alone ranged from 25 to 56%. This indicates that the fertility rate after surgical treatment of large pituitary tumors is significantly higher than that of those on medication. Therefore, in smaller pituitary tumors, surgery may be considered after the choice of drug therapy has failed. Those who are not operated or still have residual tumors after surgery are at risk of pituitary stroke during pregnancy. What should I do if I still have not had children after surgery? First, check the fertility of both men and women, and if both are normal, recheck the female partner’s prolactin level, and if it is still high, add medication. If the level is still high, additional medication should be added. If you have not conceived after 6 months of bromocriptine, other ovulation medications should be combined.