The most common manifestations of perimenopause include hot flashes, sweating, agitation, and poor night sleep, as well as cardiovascular complications such as high blood pressure, coronary heart disease, and atherosclerosis. If there are no contraindications to hormone replacement therapy, it is best to give hormone replacement therapy to slow down the above-mentioned conditions, improve the quality of life and further reduce the cardiovascular complications that occur afterwards. It is important to give high priority to the above-mentioned situation.