It is possible to be positive for Hepatitis B virus 1245 at the same time. A positive 1245 hepatitis B penta test means that it is positive for hepatitis B surface antigen, hepatitis B surface antibody, hepatitis B e antibody and hepatitis B virus core antibody. In the result of Hepatitis B test, if there are four positives of 1245 at the same time, it is rare, there are two possibilities: on the one hand, it may be that the Hepatitis B virus is in the period of recovery, and the Hepatitis B surface antigen is in the process of gradual dissipation, but it has not been dissipated completely for the time being, so the surface antigen and antibody are present at the same time, which is a kind of good phenomenon. On the other hand, another possibility is that the hepatitis B virus has mutated, at this time, it is necessary to do quantitative examination of the hepatitis B virus, if the viral infection is negative or decreasing relative to the last result, that is to say, the hepatitis B virus is recovering. If the viral load is high and continues to rise relative to the previous result, the infection has mutated. Hepatitis B virus 1245 positive should be reviewed regularly, if abnormalities occur, it is recommended to go to the hospital in time and cooperate with the doctor to actively carry out treatment.