Objective: To summarize the recent efficacy, indications and complications of multi-polar needle radiofrequency treatment for prostate cancer, and to establish the method of B-ultrasound-guided trans-perineal approach for multi-polar needle radiofrequency ablation for prostate cancer, and to summarize its clinical effects. Methods: Twelve patients with advanced prostate cancer (stage T3 or above), with an average age of 68 years, were treated with a multi-polar needle radiofrequency treatment system from Beijing Wilford. Preoperatively, routine ECT, PSA, transrectal ultrasound, CT, MRI were performed to understand the site size of prostate cancer foci, etc. Epidural anesthesia was used and the patients were in a lithotomy position. In the ablation of prostate cancer in 12 patients with prostate cancer, radiofrequency multipole needle was opened after reaching the cancer foci under the guidance of B ultrasound. The energy of radiofrequency was sequentially treated from small to large. The maximum temperature was 95℃, and each needle lasted 5-10 min. 7 needles were punctured and ablated for each patient on average, and intraoperative and postoperative complications and treatment effects were observed. The results: All 12 cases were successful, and the echogenicity of radiofrequency ablation under intraoperative ultrasound monitoring was significantly enhanced, the average treatment time was 78 min, and the urinary catheter was left in place for 7 days. 2 cases had mild postoperative hematuria, no rectal injury and urinary incontinence, and few complications. Conclusion: Rectal B-ultrasound-guided transperineal multipolar radiofrequency ablation is a minimally invasive treatment for advanced prostate cancer with definite and safe results.