Vitiligo is a common acquired pigment loss skin and mucous membrane disease that can involve hair follicles and clinically manifest as white patches or (and) white hair. The treatment of vitiligo includes topical and systemic drug therapy, phototherapy, transplantation therapy and depigmentation therapy. 1. Topical drug therapy: commonly used drugs include glucocorticoid drugs such as hydrocortisone and dexamethasone; calcium-modulated phosphatase inhibitors such as tacrolimus and pimecrolimus; and vitamin D3 derivatives such as calcipotriol and tacalcitol. 2. Systemic drug therapy: it is applicable to the patients in the progressive stage, and commonly includes glucocorticoid drugs such as prednisone. 3. phototherapy: phototherapy NB-UVB and 308nm excimer laser/light are suitable for the treatment of all types (except mucous membrane type) and stages of vitiligo. Large area irradiation need to pay attention to the eyes, face and external genitalia protection. 4. transplantation therapy: applicable to stable segmental type and unclassified patients, can be autologous epidermis or melanocyte transplantation. 5. decolorization treatment: white spot area greater than 95% of the body surface area of the patients of all kinds of repigmentation treatment resistance, in the patient request feasible decolorization treatment. Vitiligo suggests timely medical treatment, the use of specific drugs should be carried out under the guidance of the doctor.