Some patients with large cerebral infarcts can be conscious and are usually seen in the elderly. For patients with large cerebral infarction who appear unconscious, it is considered that the patient appears unconscious due to the relatively large infarct area and heavy edema, which affects the upstream reticular activation system. In elderly people, due to the presence of brain atrophy, even when large cerebral infarction and heavy cerebral edema are present, some patients do not have damage to the superior reticular activation system, so the consciousness of such patients can be clear. Large cerebral infarction is mostly seen in the blockage of the middle cerebral artery and the patient has heavy atherosclerosis. In the acute stage, the patient can be given symptomatic treatment of antiplatelet aggregation, activation of blood circulation and removal of oxygen free radicals, and at the same time, the patient should be given medication for dehydration and lowering cranial pressure, and if necessary, the patient can also be given debridement decompression. For patients with large cerebral infarction, it is also necessary to avoid the occurrence of pneumonic pneumonia and pressure sores in the acute stage.