Herpes simplex virus is characterized by a long incubation period, recurrent episodes, and neurotissue-loving; it may lead to herpes simplex virus infection and symptoms such as small blisters and pain, and in severe cases, diffuse infection of the central nervous system and multiple organs may occur. Herpes simplex virus is the earliest human herpesvirus discovered. It usually enters the human body through the respiratory tract, genital mucous membranes, and skin lesions, and lurks in mucous membranes, lacrimal glands, and salivary glands, and is activated when the body’s immunity is low, leading to herpes simplex virus infection. Herpes simplex virus infection manifests as clusters of small, multilocular blisters on the skin and mucous membranes, which are commonly found on the face, genitals, mouth, and other parts of the body, and may be accompanied by burning, itching, pain, and other symptoms, and is prone to recurrence; when the condition is severe, it may lead to a diffuse infection of the central nervous system and multiple organs, and lead to fever, generalized malaise, headache, lethargy, viremia, encephalitis, and pneumonia, among other things. Studies have shown that most of the population has been infected with herpes simplex virus, so there is no need to be overly nervous, and carrying the virus does not necessarily lead to disease; when symptoms related to herpes simplex virus infection appear, it is necessary to seek medical treatment in a timely manner, and symptomatic treatment and antiviral therapy under the guidance of doctors.