In case of major depression, early hospitalization is recommended for systematic and standardized treatment. The treatment depends on two main conditions: 1. 2. Major depression without the above mentioned conditions can be treated with medication or MECT, which is based on new antidepressants such as SSRIs, SNRIs or NaSSAs. The side effects of the new antidepressants are very small and will disappear in about 1 week, so take them according to the treatment course after the condition improves to avoid relapse.