Symptoms of severe depression, there are the following aspects: 1, depressed mood, the patient is not happy every day, depressed mood, no sense of pleasure in daily life, fatigue, weakness, lack of spirit, what to do can not raise the spirit, lack of fun, no interest in the past hobbies, normal behavior; 2, appetite and libido, the patient treats eating as a task, no sex life and sexual desire; 3, the patient may have Suicide attempts, suicide plans and suicidal behaviors can be serious, and the suicide mortality rate of depression can reach about 10%-15%; 4, the patient’s brain is unresponsive, and he feels that his brain is like rust, with difficulty in association and memory loss; 5, low self-esteem, the patient feels that he is inferior to others, always comparing his shortcomings with the strengths of others, the patient is pessimistic and desperate about the future, and feels that he is helpless in his life The patient is pessimistic and desperate about the future, feeling that he or she is helpless in this life, incompetent, powerless, and does not deserve the attention and help of others. Therefore, depression can be very damaging to people.