Craniocerebral trauma is the trauma suffered by the skull and brain after a violent impact. Generally speaking, the injury includes three aspects: 1, direct damage to the skull and brain tissue, such as skull fractures, brain contusions, etc. 2, secondary damage to brain tissue, such as intracranial hematoma, cerebral edema, acute intracranial pressure increase, etc. 3. Damage to adjacent tissues and organs, such as injury to the cervical spine, cervical medulla, and neck muscles. Headache is one of the common clinical symptoms in patients with craniocerebral trauma. As with other causes of headache, headache caused by craniocerebral trauma is also caused by injurious stimuli to the head and nearby tissues. These injurious stimuli can be summarized into three aspects: 1. pressure and irritation of pain-sensitive structures in the skull. Intracranial sensitive structures include: larger intracranial arteries, veins, venous sinuses, dura mater, and certain cranial nerves, such as the trigeminal nerve, the glossopharyngeal nerve, and the vagus nerve. 2.Extracranial tissues such as scalp, scalp blood vessels, nerves, and skull periosteum are damaged. 3. Damage to the nerves that travel through the muscles of the neck and the five senses of the head and face. The above-mentioned tissues release pain-causing substances such as potassium ion (K+), hydrogen ion (H+), histamine, bradykinin, 5-hydroxytryptamine (5-HT), prostaglandins (PGI 2, PGE 2), interleukins, leukotrienes, acetylcholine and substance P to act on nociceptive receptors under the effect of physical or chemical injurious stimuli. Since nociceptors are free nerve endings with only a layer of cell pulp on the surface, they can make direct contact with tissue fluid and easily receive the above-mentioned nociceptive chemicals to produce nociceptive signals. Through the conduction pathway of cephalic nociception, nociception is generated via the trigeminal thalamic tract, the posterior lateral nucleus of the thalamus, and the internal capsule to the cortical sensory center of the postcentral gyrus in the 1/3 of the cerebral cortex. Of course, the adjustment and integration of nociception also requires the participation of some nuclei in the brainstem, thalamus, septum, hippocampus, and cingulate gyrus.