Whether a baby with hepatitis B immunoglobulin gets one or two shots is determined by the mother’s hepatitis B condition. 1. One shot: the mother is hepatitis B surface antigen positive, E antibody positive, core antibody positive hepatitis B virus carriers, the so-called small triple Yang, within 24 hours after the birth of the baby to play a shot of hepatitis B immunoglobulin, joint application and separate injection of hepatitis B vaccine, in the full one month, six months, each respectively, can be vaccinated with a hepatitis B vaccine. 2. Two injections: if the baby mother is a hepatitis B patient who is positive for surface antigen of hepatitis B, positive for E antigen and positive for core antibody or a hepatitis B carrier, so-called triple positive, she can have one injection of hepatitis B immunoglobulin within 24 hours after the baby is born and one hepatitis B vaccine in the other arm, and then another injection of hepatitis B immunoglobulin and hepatitis B vaccine at the end of one month and another hepatitis B vaccine at the end of six months. If both or one parent has hepatitis B, it is important to follow the doctor’s instructions for hepatitis B immunoglobulin and hepatitis B vaccine. The combination of hepatitis B immunoglobulin and hepatitis B vaccine is an effective means of interrupting the transmission of hepatitis B from mother to child.