What is imbalance syndrome? How can it be prevented? The imbalance syndrome usually occurs in patients who have just started dialysis treatment, because after the high concentration of toxins in the blood of uremic patients are rapidly removed by dialysis, the osmotic pressure balance inside and outside the cells in the body is broken, and the cells will become edematous, and the edematous brain cells will cause a series of syndromes with mainly neurological symptoms, such as headache, nausea, vomiting, high blood pressure, convulsions, coma and even death. The imbalance syndrome can be effectively prevented by the method of induced dialysis, whose main purpose is to decrease the efficiency of dialysis and increase the frequency of dialysis, so that the osmotic pressure in the body slowly decreases and the internal environment of the body has a balanced adaptation process to reduce the adverse effects. However, the imbalance syndrome cannot be completely avoided, especially in patients with very high toxin levels and poor general condition. What is the first use syndrome? How is it managed? First-time use syndrome is a group of combined reactions that occur in a subset of patients due to allergies when using a new dialyzer, usually within 1 hour after the start of dialysis. In mild cases, itching, cough, runny nose, fistula or generalized fever may occur; in some cases, gastrointestinal allergy, such as abdominal pain and diarrhea; in severe cases, respiratory distress and cardiac arrest may occur. In mild cases, no special treatment can be done, but for severe reactions, dialysis should be stopped immediately and symptomatic treatment should be given accordingly. First-time use syndrome is related to patient specificity and may be reduced or avoided by replacing the filter with another model. Pretreatment with a new filter may be effective in some patients.