If the whole body is sore at night while sleeping, there are usually several factors as follows: First, the most common factor is the infectious one. Whether the body is infected with bacteria, viruses, pathogenic microorganisms, mycoplasma, chlamydia, etc., the body will release inflammatory mediators. The above-mentioned inflammatory mediators include histamine, bradykinin, leukotriene, prostacyclin, etc. When they are released in the body to wander, they will produce pain-causing factors, which will lead to the clinical symptoms and performance of body aches and pains around the body. Secondly, if the whole body is sore at night when sleeping, it also has to do with the increase in anaerobic metabolism caused by too much exercise during the day, or incorrect exercise methods and methods. Third, such as heat stroke heat cramps, heat exhaustion, pyrexia, will also appear whole body rhabdomyolysis, and the clinical symptoms and performance of the whole body aches and pains when sleeping. Fourth, some rare diseases, such as connective tissue disease, rheumatism and rheumatoid disease, may also show the above clinical symptoms and manifestations.