If the whole body is sore at night while sleeping, there are usually several factors as follows: 1. Infectious factors, whether the body is infected by bacteria, viruses, pathogenic microorganisms or fungi, such infectious substances will produce inflammatory factors in the body, such inflammatory factors include leukotrienes, bradykinin, prostacyclin and other substances. This kind of substance will cause the whole body nociceptive sensation to increase and the clinical symptoms of whole body pain. 2. Non-infectious factors will also cause whole body pain, such as rheumatism, connective tissue disease, arthritis, and also the clinical symptoms and performance of whole body pain. 3. 4. For example, peripheral neuritis can be particularly sensitive during sleep at night, resulting in painful skin all over the body.