With the development of society, people have more knowledge about mental illnesses, and the treatment of severe mental illnesses has received more and more attention from the society. Among the patients with mental illness, about 30% of them are ineffective or have recurrent episodes of traditional medical treatments such as medication, psychological counseling, and electrical stimulation, which is medically categorized as “severe mental illness” or “intractable mental illness”. At present, there are two major problems in the treatment of patients with severe mental illness: on the one hand, severe mental illness is “demonized”. As patients may be dictated by the symptoms of madness, strange behavior and other phenomena, ordinary people are afraid of them, estrangement, resulting in many patients are often closed in the “small dark room” no longer receive treatment; on the other hand, most of the patients with severe mental illness did not get the correct treatment, resulting in repeated episodes of the disease, deepening the deterioration of the condition. For patients with severe mental illness, we should hold more care. Patients are struggling a lot inside, they are often annoyed with their behaviors after their symptoms are under control, therefore, both the community and guardians or family members should give them more care, give them a warm environment, and build up the confidence to fight against the disease and actively treat them. For patients with severe mental illness, if the effect of drug treatment is poor, surgical deep brain electrical stimulation and minimally invasive surgery can be considered. For example, minimally invasive neuromodulation under brain stereotactic (referred to as brain stereotactic technology) treatment has been developed to the fifth generation. The fifth-generation brain stereotactic technology firstly examines patients with DTI, MRI, CT and other imaging medical technology, and then analyzes the imaging medical data and locates the neuromodulation target points, in order to help the patients to better control the complex mental symptoms, such as gibberish, delusion, emotional exuberance, impulsive aggressiveness, wounding and destroying things for no reason, and the symptoms of self-knowledge and unwillingness to cooperate with the treatment and take medication, etc., which can be effectively controlled after the surgery. be effectively controlled. The surgery can be completed by making a small incision of about 1-3 centimeters on the patient’s head. For patients who have poor drug sensitivity and take a lot of medication, the drug sensitivity is significantly improved after the surgery, and the amount of medication is only 1/3 of the amount before the surgery, and after the amount of medication is reduced, the side effects of the medication will also be significantly reduced. For patients who are unwilling to cooperate with the treatment due to lack of self-awareness, their self-awareness is restored after the operation, and they can consciously cooperate with the treatment and actively take the medication.