Clinical manifestations of pancreatic cancer: The clinical manifestations of pancreatic cancer depend on the location of the cancer, the early and late stage of the disease, the presence or absence of metastasis and the involvement of adjacent organs. Its clinical features are short duration of the disease, rapid development and rapid deterioration. The most common symptoms are upper abdominal fullness and discomfort and pain, as well as jaundice, digestive symptoms, emaciation, weakness, abdominal mass, diabetic symptoms and psychiatric symptoms. Certain symptoms, especially jaundice, are associated with pancreatic head cancer and suggest a relatively good prognosis. Jaundice generally occurs earlier than other symptoms of pancreatic cancer, such as back pain and fatigue. The median survival time of patients with pancreatic body or tail cancer is significantly shorter than that of patients with pancreatic head cancer, probably because pancreatic body or tail cancer often lacks clear symptoms, leading to delayed diagnosis. Even in patients treated with surgical resection and no metastases are found, patients with pancreatic body or tail cancer have a lower survival than patients with pancreatic head cancer. Is pancreatic cancer hereditary? Medical studies have shown that most patients with pancreatic cancer do not have an associated family history, but about one in ten patients is hereditary. For every immediate family member, such as a parent and sibling, who develops pancreatic cancer, the risk of developing pancreatic cancer increases by 40%. Since cancer development is a multifactorial process, there may be activation and inactivation of multiple oncogenes or oncogenes, and it is not unrelated to family genetics. How to screen and detect pancreatic cancer early? Many international research projects have attempted to use standardized screening methods in their studies. These studies have used ultrasound endoscopy as the primary imaging method to identify precancerous lesions. Early detection and early intervention of tumors using susceptibility genetic testing, individualized assessment and follow-up, and pharmacological prevention for tumors allows more patients to be detected early and treated early, resulting in better outcomes. How to prevent and treat pancreatic cancer? First of all, patients should improve their knowledge and understanding of pancreatic cancer, make a preliminary judgment whether they are at high risk of pancreatic cancer, be alert to the insidious clinical symptoms and signs of pancreatic cancer in the early stage, and go to the hospital in time. Patients should first undergo serum biochemistry and tumor marker examination, followed by gastrointestinal fluoroscopy or gastroduodenoscopy to exclude common gastrointestinal diseases; again, B-type ultrasound or CT examination should be performed, and further examination should be done for suspicious cases. For highly suspicious cases, laparoscopic or open exploratory surgery can be considered, and fine needle aspiration cells or frozen section examination can be used to obtain pathological basis during surgery.