Since the 1980s, lung cancer has become the cancer with the highest morbidity and mortality rate in the world, and there is a rising trend year by year. In China, lung cancer in Beijing, Shanghai, Guangzhou, Hefei, etc. has jumped to the top of the group of cancers, and the incidence rate rises rapidly after the age of 40, with the peak of the incidence age between 60 and 79 years old, and in recent years, lung cancer in young people is not uncommon. The prevalence rate of male and female is 2.3:1, and race, family history and smoking have influence on the incidence of lung cancer. The treatment of lung cancer varies according to the type of pathology and the location of the disease. Peripheral lung cancer: Surgery is preferred. Small chest incision and chest wall muscle retraction can well expose hilar structures and perform most of the intra-thoracic surgical operations, such as lobectomy and total pneumonectomy, which results in less trauma, less bleeding, quicker postoperative recovery, and facilitates further chemotherapy or radiotherapy. Thoracoscopic resection of lung cancer is also widely used in clinical practice. For patients who cannot receive surgical treatment, minimally invasive treatment methods can be adopted, such as argon helium knife, radiofrequency, microwave, radiotherapy particle implantation, chemotherapy particle implantation and so on. For patients with intrathoracic lymph node metastasis, targeted radiotherapy can be adopted, together with ultra-low temperature thermotherapy and systemic chemotherapy. 1.Argon helium knife Percutaneous puncture, thoracoscopic guidance or surgery combined with argon helium knife treatment can be adopted. It has been clinically proved that freezing before surgical resection of lung cancer can make the tumor tissue shrink, easy to equal volume resection and reduce intraoperative bleeding, etc. After freezing, adhesion can easily occur on the surface of tissues, reducing postoperative secondary hemorrhage and infection; freezing inflammation and immune reaction caused by cryotherapy can enhance the cellular immune function. Cryotherapy can not only achieve the role of rapid ablation, but also increase the sensitivity of radiotherapy and chemotherapy. The combination of cryotherapy and radiotherapy for non-small cell lung cancer has confirmed that the local tumor inhibition rate of radiotherapy alone is 35%, and the local tumor inhibition rate of cryotherapy alone is 65%, and the combination of these two treatments can increase the effective rate by 2~4 times, and reduce the residual rate by more than 80%. For lung cancer that cannot be surgically resected, percutaneous puncture treatment with argon helium knife has achieved very good curative effect. This method can achieve radical or palliative treatment effect for early and advanced primary lung cancer with ≤6 unilateral intra-lung foci, single foci diameter ≥0.5cm, or metastatic lung cancer whose primary cancer has been better controlled or more limited. Wang Hongwu reported that the freezing results of more than 600 cases and 700 lung cancer foci showed that the immediate freezing effect of tumor was related to the size and location of the tumor, and the smaller the tumor volume (but the diameter was more than 1 cm), the better the freezing effect was; the freezing effect of peripheral foci was better than that of central foci. For tumors ≤ 4 cm in diameter, one 2mm or 3mm probe can be used each time, with an effective rate of more than 96%, while for tumors > 4 cm in diameter, a combination of more than 2 probes is needed, with an effective rate of nearly 56%. Percutaneous puncture cryotherapy for lung cancer does not require incision and general anesthesia, and it is still effective for patients who are old and weak or who have failed in surgery, radiotherapy and chemotherapy, and it also increases the hope of treatment for patients with advanced stage. 2. Radiofrequency therapy (RFA) can adopt percutaneous puncture, thoracoscopic guidance or surgery combined with radiofrequency treatment. CT-guided percutaneous lung puncture radiofrequency treatment for lung cancer has the advantages of accurate positioning, easy control, certain efficacy, better efficacy for small lesions, less trauma, less pain, easy acceptance by patients and fewer postoperative complications. Indications: (1) Primary lung cancer that cannot be operated due to cardiopulmonary function; (2) Primary lung cancer that cannot be resected by surgery; (3) Patient’s refusal of surgery; (4) Metastatic lung cancer with fewer than 5 foci on one side of the lung; (5) Lung cancer that cannot be resected during intraoperative exploration; (6) Lung cancer that cannot be resected by chemotherapy, radiotherapy or other therapies with obvious effects. Radiofrequency therapy carries out ablation therapy under direct computer control. If the tumor diameter is less than 3cm, the RFA treatment time is 5min; if the tumor diameter is 3~4cm, the treatment time is 10min; if the tumor diameter is more than 5cm, the treatment time is 15min each time, because the effective range of ablation treatment is 4~5cm for each point, for the lesion with a large range, the ablation electrode should be changed for several times in the process of treatment, and the range of ablation should be extended to 0.5~1cm of normal tissues beyond the lesion area. For larger lesions, the ablation electrode should be replaced several times during the treatment, and the ablation range should be extended beyond the lesion area to 0.5~1cm of normal tissues to ensure that the tumor foci are completely included in the ablation electrode range of action, so as to achieve full necrosis of tumor tissues. In recent years, microwave thermo-coagulation therapy has been more and more widely used in the treatment of lung cancer, and has shown remarkable efficacy in the treatment of central lung cancer and peripheral lung cancer. CT-guided percutaneous microwave thermocoagulation for peripheral lung cancer has gained rich clinical experience. For the lesions with tumor diameter <3.0cm, generally one treatment can inactivate the tumor tissue. When the tumor is large, multi-point coagulation treatment can be divided, and the general treatment interval is 1 week. When the mass is located in the vicinity of the mediastinum, close to nerves and large blood vessels, treatment should be extremely cautious. In the treatment, attention should be paid to accurate positioning and guidance, minimize the number of puncture, and strive for a successful puncture . Particle implantation includes radiotherapy particle implantation and chemotherapy particle implantation. Particles can be implanted by percutaneous puncture or intraoperatively. The intraoperative implantation method is that after wedge resection of lung cancer, if there are suspected residual tumor tissues in the tumor bed, radioactive particles or chemotherapeutic particles can be implanted with corresponding number of particles according to three-dimensional three-dimensional treatment plan, so as to carry out accurate tumor-bed-adapted radiotherapy and chemotherapy, which will maximally kill the residual tumor cells and minimally damage the normal tissues, and thus better control the local recurrence of the tumor.