Generally antihypertensive drugs are taken in the morning, mainly on an empty stomach. If a patient has a 24-hour ambulatory blood pressure check and the blood pressure is found to be higher at night, it is recommended to take oral antihypertensive medication at night. For this group of people, before taking antihypertensive drugs at night, pay attention to the time interval of more than half an hour between eating and taking antihypertensive drugs. After taking the medication, as long as 10-20 minutes have passed, the patient has no obvious discomfort such as nausea, dry vomiting or rapid heartbeat, pale face. As long as there are no discomfort symptoms mentioned above, the patient can proceed to sleep. There is usually no discomfort or sudden hypotension during sleep. However, patients should be aware that blood pressure should be measured each time before taking antihypertensive medication, which means that blood pressure should be measured before taking medication. Systolic blood pressure should be greater than or equal to 110 mmHg, diastolic blood pressure greater than or equal to 60 mmHg, when the patient is safer to take antihypertensive drugs. If the patient’s blood pressure is less than 90mmHg systolic, diastolic less than 50mmHg, then take antihypertensive drugs, will lead to a further drop in blood pressure, will have the risk of hypotensive shock.