The more effective pain relievers for gallstones are antispasmodic and analgesic drugs, including indomethacin and diclofenac. Because the acute attack of gallstones is mostly combined with gallbladder spasm and bile duct obstruction, effective relief of spasm and bile duct obstruction can enable bile to be discharged, which has a good effect on relieving biliary colic. In addition, for some patients with more severe pain, the antispasmodic and pain relief effect is poor, and only some strong pain medications, including prescription pain medications, can be used. If severe pain cannot be relieved, it may also be necessary to give strong analgesic drugs such as dulcolax or bupropion. However, the indiscriminate use of such medications is prohibited because of the risk of masking the condition, leading to severe attacks of gallstone symptoms that go undetected, or even the risk of gallbladder perforation and rupture, as well as infectious shock. It is important to use them under the observation of a doctor and to choose the right painkiller according to the patient’s pain level. Painkillers alone sometimes do not achieve very good results and require a combination of various considerations. For example, for gallstones with more serious inflammation, symptomatic treatment with anti-infection is also needed to reduce inflammation and swelling and relieve pain. If gallstones attack and painful symptoms appear, it is recommended to go to a regular hospital for treatment, so that the doctor can choose the appropriate treatment plan for gallstones patients according to the specific situation and relieve the pain caused by gallstones. For more serious gallstones, if pain medication is ineffective and conservative treatment cannot achieve better results, surgery should be considered in time.