Unilateral swelling of lymph nodes behind the ear may be caused by inflammation of lymph nodes, tuberculosis of lymph nodes or lymphoma, etc. After examination and diagnosis, targeted drug treatment should be carried out, and radiotherapy should be considered if necessary. 1. Inflammation of lymph nodes: If the inflammation of lymph nodes behind the ear is caused by bacterial or viral infection, resulting in unilateral swelling of lymph nodes behind the ear, it is necessary to cooperate with the professional doctor to apply antibiotic drugs for anti-infective treatment, and the commonly used drugs are levofloxacin, cefradin, etc. For the enlarged lymph nodes, it is necessary to apply antibiotics to treat the infection. For the enlarged lymph nodes, you can also apply the appropriate drugs, such as mupirocin ointment, can be anti-inflammatory and reduce swelling. 2. Lymph node tuberculosis: If unilateral postauricular lymph node swelling is caused by lymph node tuberculosis, anti-tuberculosis treatment with drugs such as isoniazid, rifampicin or pyrazinamide is needed. 3. Lymphoma: If the swelling of unilateral retroauricular lymph node is caused by lymphoma, it should be considered to do puncture biopsy to clarify the benign or malignant nature of the tumor according to the guiding suggestions of professional doctors, and actively cooperate with doctors to carry out radiotherapy if necessary. If there is unilateral postauricular lymph node swelling, it is recommended to go to regular hospital for examination as soon as possible, to clarify the cause of the disease, to exclude the possibility of malignant tumors, and to carry out standardized medication and treatment in time.